課程大綱

課程資訊

課程名稱

結構生物學與生物資訊特論
Structural Biology & Bioninformatics

開課學期

106-1

授課對象

生命科學院基因體與系統生物學學位學程

授課教師

楊啟伸

課號

Biot8003

課程識別碼

642ED0040

班次

學分

3.0

全/半年

半年

必/選修

選修

上課時間

星期五6,7,8(13:20~16:20)

上課地點

生技館212

備註

本課程以英語授課。與蔡孟勳合授
限博士班
總人數上限：20人
外系人數限制：15人

Ceiba 課程網頁

http://ceiba.ntu.edu.tw/1061Biot8003_

課程簡介影片

核心能力關聯

核心能力與課程規劃關聯圖

課程大綱

為確保您我的權利,請尊重智慧財產權及不得非法影印

課程概述

This is a class integrates the concepts of structural biology and bioinformatics. The basic principles of amino acids and structural biology will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatics principles, methods and modern developments will be followed.

課程目標

1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of bioinformatics methods.

課程要求

This class will be taught in English.

預期每週課後學習時數

Office Hours

指定閱讀

Most recent published journal articles.

參考書目

1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated when new developments occur.

評量方式
(僅供參考)

No.	項目	百分比	說明
1.	Final exam	50%	Bioinformatic part could composed of presentation, too.
2.	Mid-term	30%
3.	Presentation	20%	In Structural Biology part.

課程進度

週次	日期	單元主題
第1週	9/15	Introduction to structural biology. Software for structural biology
第2週	9/22	Software tools for structural biology Amino acids and protein structures (1/2)
第3週	9/29	Amino Acids and protein structures (2/2) 1. Basic protein structure
第4週	10/06	Amino acids and structure Protein Structure and Functions Functional domain
第5週	10/13	Modern methods for structural biology (1): PDB display software
第6週	10/20	Modern methods for structural biology (2): X-ray diffraction & CryoEM
第7週	10/27	BYOC: Bring your own computer; Let's do animation! Life science and structural biology (1): Cellular functions, Membrane proteins
第8週	11/03	Bioinformatics and Software Tools Demonstration
第9週	11/10	Oral presentation Midterm Exam (Final for Structural Biology)
第10週	11/17	Introduction of bioinformatics
第11週	11/24	Transcriptome: Microarray introduction (1)
第12週	12/01	Microarry (2): Data analysis
第13週	12/08	NTUMAPs and IPA demostration
第14週	12/15	NGS introduction
第15週	12/22	NGS partek flow demonstration
第16週	12/27	Genetic and population analysis: SNP introduction
第17週	1/05	DNA copy number variation
第18週	1/12	Final Exam